Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo.
Identifieur interne : 000240 ( Main/Exploration ); précédent : 000239; suivant : 000241Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo.
Auteurs : Shyh-Horng Lin [Taïwan] ; Ming-Han Li [Taïwan] ; Kai-An Chuang [Taïwan] ; Ni-Hsuan Lin [Taïwan] ; Chih-Hsuan Chang [Taïwan] ; Hsin-Chieh Wu [Taïwan] ; Ya-Hsuan Chao [Taïwan] ; Chi-Chien Lin [Taïwan] ; I-Hong Pan [Taïwan] ; Ming-Der Perng [Taïwan] ; Shu-Fang Wen [Taïwan]Source :
- Oxidative medicine and cellular longevity [ 1942-0994 ] ; 2020.
Descripteurs français
- KwdFr :
- Antigènes CD11b (métabolisme), Antinéoplasiques (effets indésirables), Cellules HL-60 (MeSH), Cellules de la moelle osseuse (anatomopathologie), Cellules de la moelle osseuse (effets des médicaments et des substances chimiques), Cellules myéloïdes (anatomopathologie), Cellules myéloïdes (effets des médicaments et des substances chimiques), Chlorella (MeSH), Cisplatine (effets indésirables), Cisplatine (usage thérapeutique), Effets secondaires indésirables des médicaments (traitement médicamenteux), Extraits de plantes (usage thérapeutique), Facteur de stimulation des colonies de granulocytes et de macrophages (métabolisme), Humains (MeSH), Immunomodulation (MeSH), Immunosuppression thérapeutique (MeSH), Mitochondries (métabolisme).
- MESH :
- anatomopathologie : Cellules de la moelle osseuse, Cellules myéloïdes.
- effets des médicaments et des substances chimiques : Cellules de la moelle osseuse, Cellules myéloïdes.
- effets indésirables : Antinéoplasiques, Cisplatine.
- métabolisme : Antigènes CD11b, Facteur de stimulation des colonies de granulocytes et de macrophages, Mitochondries.
- traitement médicamenteux : Effets secondaires indésirables des médicaments.
- usage thérapeutique : Cisplatine, Extraits de plantes.
- Cellules HL-60, Chlorella, Humains, Immunomodulation, Immunosuppression thérapeutique.
English descriptors
- KwdEn :
- Antineoplastic Agents (adverse effects), Bone Marrow Cells (drug effects), Bone Marrow Cells (pathology), CD11b Antigen (metabolism), Chlorella (MeSH), Cisplatin (adverse effects), Cisplatin (therapeutic use), Drug-Related Side Effects and Adverse Reactions (drug therapy), Granulocyte-Macrophage Colony-Stimulating Factor (metabolism), HL-60 Cells (MeSH), Humans (MeSH), Immunomodulation (MeSH), Immunosuppression (MeSH), Mitochondria (metabolism), Myeloid Cells (drug effects), Myeloid Cells (pathology), Plant Extracts (therapeutic use).
- MESH :
- chemical , adverse effects : Antineoplastic Agents, Cisplatin.
- drug effects : Bone Marrow Cells, Myeloid Cells.
- drug therapy : Drug-Related Side Effects and Adverse Reactions.
- chemical , metabolism : CD11b Antigen, Granulocyte-Macrophage Colony-Stimulating Factor, Mitochondria.
- pathology : Bone Marrow Cells, Myeloid Cells.
- chemical , therapeutic use : Cisplatin, Plant Extracts.
- Chlorella, HL-60 Cells, Humans, Immunomodulation, Immunosuppression.
Abstract
Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted.
DOI: 10.1155/2020/7353618
PubMed: 32047579
PubMed Central: PMC7003270
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><i>Chlorella sorokiniana</i> Extract Prevents Cisplatin-Induced Myelotoxicity <i>In Vitro</i> and <i>In Vivo</i>.</title><author><name sortKey="Lin, Shyh Horng" sort="Lin, Shyh Horng" uniqKey="Lin S" first="Shyh-Horng" last="Lin">Shyh-Horng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ming Han" sort="Li, Ming Han" uniqKey="Li M" first="Ming-Han" last="Li">Ming-Han Li</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Chuang, Kai An" sort="Chuang, Kai An" uniqKey="Chuang K" first="Kai-An" last="Chuang">Kai-An Chuang</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ni Hsuan" sort="Lin, Ni Hsuan" uniqKey="Lin N" first="Ni-Hsuan" last="Lin">Ni-Hsuan Lin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013</wicri:regionArea><wicri:noRegion>Hsinchu 30013</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Chih Hsuan" sort="Chang, Chih Hsuan" uniqKey="Chang C" first="Chih-Hsuan" last="Chang">Chih-Hsuan Chang</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Hsin Chieh" sort="Wu, Hsin Chieh" uniqKey="Wu H" first="Hsin-Chieh" last="Wu">Hsin-Chieh Wu</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Chao, Ya Hsuan" sort="Chao, Ya Hsuan" uniqKey="Chao Y" first="Ya-Hsuan" last="Chao">Ya-Hsuan Chao</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chi Chien" sort="Lin, Chi Chien" uniqKey="Lin C" first="Chi-Chien" last="Lin">Chi-Chien Lin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Pan, I Hong" sort="Pan, I Hong" uniqKey="Pan I" first="I-Hong" last="Pan">I-Hong Pan</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Perng, Ming Der" sort="Perng, Ming Der" uniqKey="Perng M" first="Ming-Der" last="Perng">Ming-Der Perng</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013</wicri:regionArea><wicri:noRegion>Hsinchu 30013</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Shu Fang" sort="Wen, Shu Fang" uniqKey="Wen S" first="Shu-Fang" last="Wen">Shu-Fang Wen</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32047579</idno><idno type="pmid">32047579</idno><idno type="doi">10.1155/2020/7353618</idno><idno type="pmc">PMC7003270</idno><idno type="wicri:Area/Main/Corpus">000215</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000215</idno><idno type="wicri:Area/Main/Curation">000215</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000215</idno><idno type="wicri:Area/Main/Exploration">000215</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en"><i>Chlorella sorokiniana</i> Extract Prevents Cisplatin-Induced Myelotoxicity <i>In Vitro</i> and <i>In Vivo</i>.</title><author><name sortKey="Lin, Shyh Horng" sort="Lin, Shyh Horng" uniqKey="Lin S" first="Shyh-Horng" last="Lin">Shyh-Horng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ming Han" sort="Li, Ming Han" uniqKey="Li M" first="Ming-Han" last="Li">Ming-Han Li</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Chuang, Kai An" sort="Chuang, Kai An" uniqKey="Chuang K" first="Kai-An" last="Chuang">Kai-An Chuang</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ni Hsuan" sort="Lin, Ni Hsuan" uniqKey="Lin N" first="Ni-Hsuan" last="Lin">Ni-Hsuan Lin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013</wicri:regionArea><wicri:noRegion>Hsinchu 30013</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Chih Hsuan" sort="Chang, Chih Hsuan" uniqKey="Chang C" first="Chih-Hsuan" last="Chang">Chih-Hsuan Chang</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Hsin Chieh" sort="Wu, Hsin Chieh" uniqKey="Wu H" first="Hsin-Chieh" last="Wu">Hsin-Chieh Wu</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Chao, Ya Hsuan" sort="Chao, Ya Hsuan" uniqKey="Chao Y" first="Ya-Hsuan" last="Chao">Ya-Hsuan Chao</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chi Chien" sort="Lin, Chi Chien" uniqKey="Lin C" first="Chi-Chien" last="Lin">Chi-Chien Lin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Pan, I Hong" sort="Pan, I Hong" uniqKey="Pan I" first="I-Hong" last="Pan">I-Hong Pan</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author><author><name sortKey="Perng, Ming Der" sort="Perng, Ming Der" uniqKey="Perng M" first="Ming-Der" last="Perng">Ming-Der Perng</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013</wicri:regionArea><wicri:noRegion>Hsinchu 30013</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Shu Fang" sort="Wen, Shu Fang" uniqKey="Wen S" first="Shu-Fang" last="Wen">Shu-Fang Wen</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011</wicri:regionArea><wicri:noRegion>Hsinchu 30011</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative medicine and cellular longevity</title><idno type="eISSN">1942-0994</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (adverse effects)</term><term>Bone Marrow Cells (drug effects)</term><term>Bone Marrow Cells (pathology)</term><term>CD11b Antigen (metabolism)</term><term>Chlorella (MeSH)</term><term>Cisplatin (adverse effects)</term><term>Cisplatin (therapeutic use)</term><term>Drug-Related Side Effects and Adverse Reactions (drug therapy)</term><term>Granulocyte-Macrophage Colony-Stimulating Factor (metabolism)</term><term>HL-60 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Immunomodulation (MeSH)</term><term>Immunosuppression (MeSH)</term><term>Mitochondria (metabolism)</term><term>Myeloid Cells (drug effects)</term><term>Myeloid Cells (pathology)</term><term>Plant Extracts (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes CD11b (métabolisme)</term><term>Antinéoplasiques (effets indésirables)</term><term>Cellules HL-60 (MeSH)</term><term>Cellules de la moelle osseuse (anatomopathologie)</term><term>Cellules de la moelle osseuse (effets des médicaments et des substances chimiques)</term><term>Cellules myéloïdes (anatomopathologie)</term><term>Cellules myéloïdes (effets des médicaments et des substances chimiques)</term><term>Chlorella (MeSH)</term><term>Cisplatine (effets indésirables)</term><term>Cisplatine (usage thérapeutique)</term><term>Effets secondaires indésirables des médicaments (traitement médicamenteux)</term><term>Extraits de plantes (usage thérapeutique)</term><term>Facteur de stimulation des colonies de granulocytes et de macrophages (métabolisme)</term><term>Humains (MeSH)</term><term>Immunomodulation (MeSH)</term><term>Immunosuppression thérapeutique (MeSH)</term><term>Mitochondries (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Agents</term><term>Cisplatin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules de la moelle osseuse</term><term>Cellules myéloïdes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bone Marrow Cells</term><term>Myeloid Cells</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cellules de la moelle osseuse</term><term>Cellules myéloïdes</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antinéoplasiques</term><term>Cisplatine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>CD11b Antigen</term><term>Granulocyte-Macrophage Colony-Stimulating Factor</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD11b</term><term>Facteur de stimulation des colonies de granulocytes et de macrophages</term><term>Mitochondries</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone Marrow Cells</term><term>Myeloid Cells</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cisplatin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Cisplatine</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chlorella</term><term>HL-60 Cells</term><term>Humans</term><term>Immunomodulation</term><term>Immunosuppression</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HL-60</term><term>Chlorella</term><term>Humains</term><term>Immunomodulation</term><term>Immunosuppression thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. <i>Chlorella sorokiniana</i> (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32047579</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>21</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1942-0994</ISSN><JournalIssue CitedMedium="Internet"><Volume>2020</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Oxidative medicine and cellular longevity</Title><ISOAbbreviation>Oxid Med Cell Longev</ISOAbbreviation></Journal><ArticleTitle><i>Chlorella sorokiniana</i> Extract Prevents Cisplatin-Induced Myelotoxicity <i>In Vitro</i> and <i>In Vivo</i>.</ArticleTitle><Pagination><MedlinePgn>7353618</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2020/7353618</ELocationID><Abstract><AbstractText>Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. <i>Chlorella sorokiniana</i> (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies. However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted.</AbstractText><CopyrightInformation>Copyright © 2020 Shyh-Horng Lin et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Shyh-Horng</ForeName><Initials>SH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5290-9265</Identifier><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ming-Han</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chuang</LastName><ForeName>Kai-An</ForeName><Initials>KA</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0870-4198</Identifier><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Ni-Hsuan</ForeName><Initials>NH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4524-3615</Identifier><AffiliationInfo><Affiliation>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Chih-Hsuan</ForeName><Initials>CH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1827-6940</Identifier><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Hsin-Chieh</ForeName><Initials>HC</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2000-4127</Identifier><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chao</LastName><ForeName>Ya-Hsuan</ForeName><Initials>YH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8283-6589</Identifier><AffiliationInfo><Affiliation>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Chi-Chien</ForeName><Initials>CC</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1464-0231</Identifier><AffiliationInfo><Affiliation>Institute of Biomedical Science, National Chung-Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>I-Hong</ForeName><Initials>IH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9959-6224</Identifier><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perng</LastName><ForeName>Ming-Der</ForeName><Initials>MD</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1884-3714</Identifier><AffiliationInfo><Affiliation>Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, 101 Kuang Fu 2 Road, Hsinchu 30013, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Shu-Fang</ForeName><Initials>SF</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9066-553X</Identifier><AffiliationInfo><Affiliation>Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 321 Kuang Fu 2 Road, Hsinchu 30011, Taiwan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Oxid Med Cell Longev</MedlineTA><NlmUniqueID>101479826</NlmUniqueID><ISSNLinking>1942-0994</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039481">CD11b Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>83869-56-1</RegistryNumber><NameOfSubstance UI="D016178">Granulocyte-Macrophage Colony-Stimulating Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q20Q21Q62J</RegistryNumber><NameOfSubstance UI="D002945">Cisplatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001854" MajorTopicYN="N">Bone Marrow Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D039481" MajorTopicYN="N">CD11b Antigen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002708" MajorTopicYN="N">Chlorella</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002945" MajorTopicYN="N">Cisplatin</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064420" MajorTopicYN="N">Drug-Related Side Effects and Adverse Reactions</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016178" MajorTopicYN="N">Granulocyte-Macrophage Colony-Stimulating Factor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018922" MajorTopicYN="N">HL-60 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056747" MajorTopicYN="N">Immunomodulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D022423" MajorTopicYN="N">Myeloid Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList><CoiStatement>The authors declare that there is no conflict of interest regarding the publication of this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>10</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>12</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32047579</ArticleId><ArticleId IdType="doi">10.1155/2020/7353618</ArticleId><ArticleId IdType="pmc">PMC7003270</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2008 Jul;9(7):532-42</Citation><ArticleIdList><ArticleId IdType="pubmed">18568041</ArticleId></ArticleIdList></Reference><Reference><Citation>Prog Nucleic Acid Res Mol Biol. 2001;67:93-130</Citation><ArticleIdList><ArticleId IdType="pubmed">11525387</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Chem. 2008;15(26):2656-63</Citation><ArticleIdList><ArticleId IdType="pubmed">18991628</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1987 Oct;84(20):7134-8</Citation><ArticleIdList><ArticleId IdType="pubmed">3499607</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2005 Aug;78(2):533-43</Citation><ArticleIdList><ArticleId IdType="pubmed">15894585</ArticleId></ArticleIdList></Reference><Reference><Citation>Food Chem Toxicol. 2015 Jul;81:120-128</Citation><ArticleIdList><ArticleId IdType="pubmed">25910835</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2000 Aug;2(8):469-75</Citation><ArticleIdList><ArticleId IdType="pubmed">10934466</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1996 Oct 18;87(2):171</Citation><ArticleIdList><ArticleId IdType="pubmed">8861900</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurobiol Dis. 2011 Mar;41(3):661-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21145397</ArticleId></ArticleIdList></Reference><Reference><Citation>Nitric Oxide. 2016 Jul 1;57:15-20</Citation><ArticleIdList><ArticleId IdType="pubmed">27095538</ArticleId></ArticleIdList></Reference><Reference><Citation>Neoplasia. 2008 Oct;10(10):1105-19</Citation><ArticleIdList><ArticleId IdType="pubmed">18813359</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Metab Dispos. 2002 Feb;30(2):183-90</Citation><ArticleIdList><ArticleId IdType="pubmed">11792689</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Death Dis. 2014 Jan 30;5:e1027</Citation><ArticleIdList><ArticleId IdType="pubmed">24481441</ArticleId></ArticleIdList></Reference><Reference><Citation>Evid Based Complement Alternat Med. 2012;2012:735396</Citation><ArticleIdList><ArticleId IdType="pubmed">23304212</ArticleId></ArticleIdList></Reference><Reference><Citation>Bio Protoc. 2015 Oct 20;5(20):</Citation><ArticleIdList><ArticleId IdType="pubmed">27441207</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytometry A. 2004 Oct;61(2):162-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15382028</ArticleId></ArticleIdList></Reference><Reference><Citation>Drugs. 2001;61(5):641-84</Citation><ArticleIdList><ArticleId IdType="pubmed">11368288</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Immunopharmacol. 2003 Jun;3(6):889-900</Citation><ArticleIdList><ArticleId IdType="pubmed">12781705</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2008 Feb;25(4):425-34</Citation><ArticleIdList><ArticleId IdType="pubmed">18092837</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 1996 Dec;104 Suppl 6:1227-34</Citation><ArticleIdList><ArticleId IdType="pubmed">9118897</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Immunol Immunother. 1998 Feb;45(6):313-20</Citation><ArticleIdList><ArticleId IdType="pubmed">9490201</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Oncol. 2008 Mar;19(3):454-60</Citation><ArticleIdList><ArticleId IdType="pubmed">18083689</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Cancer. 2015 Aug 08;15:577</Citation><ArticleIdList><ArticleId IdType="pubmed">26253167</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Chemother Pharmacol. 1992;29(6):435-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1314712</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2015 Dec 1;6(38):40734-46</Citation><ArticleIdList><ArticleId IdType="pubmed">26486083</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Biochem Biophys. 1983 Sep;225(2):640-8</Citation><ArticleIdList><ArticleId IdType="pubmed">6625604</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Death Dis. 2014 May 29;5:e1257</Citation><ArticleIdList><ArticleId IdType="pubmed">24874729</ArticleId></ArticleIdList></Reference><Reference><Citation>Aust J Exp Biol Med Sci. 1966 Jun;44(3):287-99</Citation><ArticleIdList><ArticleId IdType="pubmed">4164182</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 1987 Jul;70(1):271-5</Citation><ArticleIdList><ArticleId IdType="pubmed">3297203</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Med. 2018 Oct;42(4):2089-2097</Citation><ArticleIdList><ArticleId IdType="pubmed">30066840</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2008 Apr 25;30(2):123-35</Citation><ArticleIdList><ArticleId IdType="pubmed">18439892</ArticleId></ArticleIdList></Reference><Reference><Citation>J Agric Food Chem. 2010 Jan 27;58(2):927-36</Citation><ArticleIdList><ArticleId IdType="pubmed">19916503</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2000 Oct;20(19):7146-59</Citation><ArticleIdList><ArticleId IdType="pubmed">10982831</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Cancer. 2005 Jan;5(1):65-72</Citation><ArticleIdList><ArticleId IdType="pubmed">15630416</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Res. 2001 Oct;44(4):317-20</Citation><ArticleIdList><ArticleId IdType="pubmed">11592867</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Lett. 1998 Apr;61(2-3):157-63</Citation><ArticleIdList><ArticleId IdType="pubmed">9657269</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2008 Jun 15;22(12):1577-90</Citation><ArticleIdList><ArticleId IdType="pubmed">18559474</ArticleId></ArticleIdList></Reference><Reference><Citation>Oxid Med Cell Longev. 2017;2017:5414297</Citation><ArticleIdList><ArticleId IdType="pubmed">29181126</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1960-1969</Citation><ArticleIdList><ArticleId IdType="pubmed">28506882</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Mar 11;280(10):9005-12</Citation><ArticleIdList><ArticleId IdType="pubmed">15632129</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine. 2008 Jun;42(3):277-88</Citation><ArticleIdList><ArticleId IdType="pubmed">18400509</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Cancer Ther Rev. 2006 Aug 1;2(3):271-279</Citation><ArticleIdList><ArticleId IdType="pubmed">19936034</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013 Nov 19;8(11):e81162</Citation><ArticleIdList><ArticleId IdType="pubmed">24260552</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Cancer. 2007 Aug;7(8):573-84</Citation><ArticleIdList><ArticleId IdType="pubmed">17625587</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Med. 2006 Sep;18(3):511-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16865238</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 1997 Mar 17;232(2):317-22</Citation><ArticleIdList><ArticleId IdType="pubmed">9125172</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2002 Oct 4;297(4):1058-61</Citation><ArticleIdList><ArticleId IdType="pubmed">12359263</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Aug 13;274(33):22932-40</Citation><ArticleIdList><ArticleId IdType="pubmed">10438458</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunopharmacology. 1997 Jan;35(3):273-82</Citation><ArticleIdList><ArticleId IdType="pubmed">9043941</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2006 Oct 1;12(19):5817-25</Citation><ArticleIdList><ArticleId IdType="pubmed">17020989</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomark Insights. 2016 Aug 24;11:113-21</Citation><ArticleIdList><ArticleId IdType="pubmed">27594783</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2005 Feb 25;120(4):483-95</Citation><ArticleIdList><ArticleId IdType="pubmed">15734681</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2000 Aug 15;19(16):4310-22</Citation><ArticleIdList><ArticleId IdType="pubmed">10944114</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann N Y Acad Sci. 2003 Dec;1010:153-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15033711</ArticleId></ArticleIdList></Reference><Reference><Citation>Cold Spring Harb Protoc. 2014 Oct 01;2014(10):pdb.prot080002</Citation><ArticleIdList><ArticleId IdType="pubmed">25275104</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1995 Jul 6;376(6535):37-43</Citation><ArticleIdList><ArticleId IdType="pubmed">7596430</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Complement Altern Med. 2017 Feb 1;17(1):88</Citation><ArticleIdList><ArticleId IdType="pubmed">28143460</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Urol. 2011 Apr;8(4):213-22</Citation><ArticleIdList><ArticleId IdType="pubmed">21403662</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncol Rep. 2013 Apr;29(4):1285-92</Citation><ArticleIdList><ArticleId IdType="pubmed">23404427</ArticleId></ArticleIdList></Reference><Reference><Citation>Food Chem Toxicol. 2004 Aug;42(8):1291-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15207380</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2000 Aug 18;275(33):25665-71</Citation><ArticleIdList><ArticleId IdType="pubmed">10806214</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Toxicol. 2015 Aug;89(8):1209-26</Citation><ArticleIdList><ArticleId IdType="pubmed">26047665</ArticleId></ArticleIdList></Reference><Reference><Citation>Leukemia. 2015 Nov;29(11):2266-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25921248</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Neurobiol. 2017 Dec;54(10):7883-7895</Citation><ArticleIdList><ArticleId IdType="pubmed">27858292</ArticleId></ArticleIdList></Reference><Reference><Citation>J Agric Food Chem. 2010 Aug 11;58(15):8522-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20617828</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Oncol. 1998 Sep;16(9):3179-90</Citation><ArticleIdList><ArticleId IdType="pubmed">9738590</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lin, Shyh Horng" sort="Lin, Shyh Horng" uniqKey="Lin S" first="Shyh-Horng" last="Lin">Shyh-Horng Lin</name></noRegion><name sortKey="Chang, Chih Hsuan" sort="Chang, Chih Hsuan" uniqKey="Chang C" first="Chih-Hsuan" last="Chang">Chih-Hsuan Chang</name><name sortKey="Chao, Ya Hsuan" sort="Chao, Ya Hsuan" uniqKey="Chao Y" first="Ya-Hsuan" last="Chao">Ya-Hsuan Chao</name><name sortKey="Chuang, Kai An" sort="Chuang, Kai An" uniqKey="Chuang K" first="Kai-An" last="Chuang">Kai-An Chuang</name><name sortKey="Li, Ming Han" sort="Li, Ming Han" uniqKey="Li M" first="Ming-Han" last="Li">Ming-Han Li</name><name sortKey="Lin, Chi Chien" sort="Lin, Chi Chien" uniqKey="Lin C" first="Chi-Chien" last="Lin">Chi-Chien Lin</name><name sortKey="Lin, Ni Hsuan" sort="Lin, Ni Hsuan" uniqKey="Lin N" first="Ni-Hsuan" last="Lin">Ni-Hsuan Lin</name><name sortKey="Pan, I Hong" sort="Pan, I Hong" uniqKey="Pan I" first="I-Hong" last="Pan">I-Hong Pan</name><name sortKey="Perng, Ming Der" sort="Perng, Ming Der" uniqKey="Perng M" first="Ming-Der" last="Perng">Ming-Der Perng</name><name sortKey="Wen, Shu Fang" sort="Wen, Shu Fang" uniqKey="Wen S" first="Shu-Fang" last="Wen">Shu-Fang Wen</name><name sortKey="Wu, Hsin Chieh" sort="Wu, Hsin Chieh" uniqKey="Wu H" first="Hsin-Chieh" last="Wu">Hsin-Chieh Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantImRecepV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000240 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000240 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PlantImRecepV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32047579
|texte= Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32047579" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PlantImRecepV1
| This area was generated with Dilib version V0.6.38. |  |